Use of compounds for the elevation of pyruvate dehydrogenase activity

摘要

The use of compounds of the formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs:wherein:Ring C is phenyl or a carbon linked heteroaryl ring substituted as defmed within;R1 is an ortho substituent as defined within;n is 1 or 2;A-B is a linking group as defined within;R2 and R3 are as defined within;R4 is hydroxy, hydrogen, halo, amino or methyl; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described.