发明名称 |
Process for the production of a reversibly inactive acidified plasmin composition |
摘要 |
Disclosed is both a process for producing a reversibly inactive acidified plasmin by activating plasminogen and a process for producing a purified plasminogen. The produced plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The purified plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II+III chromatographic process and eluded at a low pH. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy.
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申请公布号 |
US2002192794(A1) |
申请公布日期 |
2002.12.19 |
申请号 |
US20020143156 |
申请日期 |
2002.05.10 |
申请人 |
DADD CHRISTOPHER A.;STENLAND CHRISTOPHER J.;KENT JONATHAN D.;KORNEYEVA MARINA N.;BAUMBACH GEORGE A.;COOK SCOOT A.;BRADLEY RITA T.;NOVOKHATNY VALERY;VILLINES TANETTE B. |
发明人 |
DADD CHRISTOPHER A.;STENLAND CHRISTOPHER J.;KENT JONATHAN D.;KORNEYEVA MARINA N.;BAUMBACH GEORGE A.;COOK SCOOT A.;BRADLEY RITA T.;NOVOKHATNY VALERY;VILLINES TANETTE B. |
分类号 |
C12N9/99;A61B17/00;A61K9/19;A61K38/00;A61K38/48;A61K47/02;A61K47/10;A61K47/12;A61K47/18;A61K47/22;A61K47/26;A61K47/36;A61K47/42;A61M25/00;A61P7/02;A61P9/10;C12N9/68;C12N9/96;(IPC1-7):C12N9/68 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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