Novel human tumor suppressor gene

摘要

A novel human progestin-regulated gene designated EDD (E3 isolated by Differential Display) is disclosed which armino acid sequence identity with the HYD protein (hyperplastic discs) from Drosophila melanogaster and the 100 kDa HECT (homologous to E6-AP carboxyl terminus) domain protein From rat. The EDD gene appears to represent a tumour suppressor gene and the detaection of a polymorphism or alteration in the gene from a subject may be useful for the diagnosis or determination of a predisposition to hyperproliferative disease such as a cancer. An assay for assessing progestin-responsiveness in a subject is also disclosed.