MUSCLE-SPECIFIC EXPRESSION VECTORS

摘要

The invention is directed to novel combinations of muscle-specifi c enhancer and promoter elements useful for achieving persistent expression in the muscle or myocytes. The muscle-specific promoter elements are derived from a muscle creatine kinase promoter, a troponin I promoter, a skeletal alpha-actin promoter, or a desmin promoter. The muscle-specific enhancer elements are derived from either troponin I internal regulatory elements, muscle creatin e kinase enhancers, or desmin enhancers.