METHOD FOR DETERMINATION OF CO-OCCURENCES OF ATTRIBUTES

摘要

A method, system, computer program selecting attribute sets of characterizin g attributes of an object, selecting an attribute set of attributes of interes t, assigning a likelihood for each characterized attribute set that the attribu te set occurs when the attribute set of interest occurs (each likelihood determined using Bayesian computable classifiers on a dataset of attributes for actual samples), comparing each assigned likelihood against likelihood thresholds, and reporting the assigned likelihoods of the characterizing attribute set based on the likelihood thresholds. Markers may be identified for diagnosis and prognosis. Characterizing attributes may be gene expressio n levels and the attribute of interest may be drug sensitivity level, drug dos e (absolute concentration or dose relative to some standard dose), dose of dru g which causes half-maximal cellular growth rate, or logarithm base 10 (dose) where dose is the dose which yields half-maximal total cell mass accumulatin g.