| 摘要 |
PROBLEM TO BE SOLVED: To provide a medicinal composition useful as a prophylactic or therapeutic agent of penile impotentia erigendi or the like because of exhibiting excellent selective PDE V (cGMP-specific phosphodiesterase)-inhibiting activities. SOLUTION: This medicinal composition contains an aromatic nitrogen- containing six-membered ring compound represented by general formula (I) [wherein, ring A is a nitrogen-containing heterocyclic group which may be substituted; R<1> is a lower alkyl group which may be substituted, a group represented by the formula: -NH-Q-R<3> (wherein, R<3> is a nitrogen-containing heterocyclic group which may be substituted; and Q is a lower alkylene group or a single bond) or a group represented by the formula: -NH-R<4> (wherein, R<4> is a cycloalkyl group which may be substituted); R<2> is an aryl group which may be substituted; one of Y and Z is a group represented by the formula: =CH-, and the other is a group represented by the formula: =N-] or a pharmacologically acceptable salt thereof as an active ingredient.
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