GASTROKINES AND DERIVED PEPTIDES INCLUDING INHIBITORS

摘要

A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designed AMP-18. AMP 18 genomic DNA, cDNA and the AMP- 18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP- 18 protein. Control of mammalian gastro-intestinal tissues growth and repair is facilitated by the use of the proteins, making the proteins candidates for therapies.