发明名称 |
Preparation of high purity citalopram comprises a cyanide exchange reaction followed by thin film distillation and recrystallization from methanol and water |
摘要 |
Preparation of citalopram (I) by subjecting a corresponding compound (II) to a cyanide exchange reaction, is new. Preparation of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo furan-carbonitrile) of formula (I) by subjecting a corresponding compound of formula (II) to a cyanide exchange reaction, followed by initial purification to give crude citalopram base, subjecting the crude product to film distillation and optionally further purifying, working up and isolating pure citalopram, is new. Z = I, Br, Cl or CF3(CF2)nSO2O-; and n = 0-8.
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申请公布号 |
DE10112828(C1) |
申请公布日期 |
2002.11.21 |
申请号 |
DE20011012828 |
申请日期 |
2001.03.16 |
申请人 |
H. LUNDBECK A/S, KOPENHAGEN/KOEBENHAVN |
发明人 |
CASTELLIN, ANDREA;VOLPE, GIULIO;SBROGIO, FEDERICO |
分类号 |
A61P25/24;C07D307/87;(IPC1-7):C07D307/87;A61K31/343 |
主分类号 |
A61P25/24 |
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