PRODUCTION METHOD OF QUINOLINECARBOXYLIC ESTER DERIVATIVE OR ITS SULFONATE

摘要

PROBLEM TO BE SOLVED: To provide an advantageous production method of 2-cyclopropyl-4-(4'- fluorophenyl)quinoline-3-carboxylic ester or its p-toluenesulfonate, which are useful as raw materials for pharmaceuticals. SOLUTION: 3-Cyclopropyl-3-oxopropanoic ester and 2-amino-4'- fluorobenzophenone are reacted, in the presence of an organic sulfonic acid, within a mixed solvent of an aliphatic solvent and an aromatic solvent.