| 摘要 |
Bovine aggrecanase-1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize bovine aggrecanase-1. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: osteoarthritis, rheumatoid arthritis, joint injury, reactive and psoriatic arthritis and other diseases of bone.
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