ACTIVATION OF NATURAL KILLER CELLS BY ADENOSINE A3 RECEPTOR AGONISTS

摘要

The present invention is based on the surprising finding that adenosine A3 receptor agonists (A3RAg) activate natural killer (NK) cells. This activation was abolished in the presence of an adenosine A3 receptor antagonist. One example of an A3RAg which exhibited this novel effect is Cl-IB-MECA.Thus, the present invention concerns the use of A3RAgs for the preparation of pharmaceutical compositions having a therapeutic effect, the therapeutic effect comprising activation of NK cells. Further, the present invention concerns therapeutic methods and pharmaceutical compositions for achieving a therapeutic effect, the therapeutic effect comprises activating NK cells by the A3RAg.