POLYMORPHS OF FEXOFENADINE HYDROCHLORIDE

摘要

The present invention provides novel crystal forms of fexofenadine hydrochloride Forms (V, VI and VIII through XV) and processes for their preparation and preparation of amorphous form and other crystalline forms of fexofenadine hydrochloride. Forms (XIV and XV) are solvates of ethyl acetate , while Form IX is anhydrous, but can be crystallized as solvate of MTBE or cyclohexane. The forms are useful for administration to humans and animals t o alleviate symptoms caused by histamine. The present invention further provid es pharmaceutical compositions of the new crystalline forms.