发明名称 |
NUCLEIC ACID VACCINES FOR PREVENTION OF FLAVIVIRUS INFECTION |
摘要 |
<p>The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus or of a chimeric immunogenic flavivirus antigen comprising sequence from more than one flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or diagnosing flavivirus infection.</p> |
申请公布号 |
WO02081754(A1) |
申请公布日期 |
2002.10.17 |
申请号 |
WO2002US10764 |
申请日期 |
2002.04.04 |
申请人 |
THE GOVERNEMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION;CHANG, GWONG-JEN, J. |
发明人 |
CHANG, GWONG-JEN, J. |
分类号 |
C12N15/09;A61K31/711;A61K39/00;A61K39/12;A61K48/00;A61P31/14;C07K14/18;C07K16/10;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/40;C12Q1/70;G01N33/53;G01N33/569;(IPC1-7):C12Q1/70;C07K16/00;C12P21/06;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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