| 摘要 |
In the present invention we describe a vehicle for the transport of biologically active or therapeutic agents into organisms, such as human beings. The vehicle described in the present invention comprises mucin, wherein said mucin is present in a natural or modified form. The mucin component of the vehicle, serves to enhance the transport of biologically active agents, such as therapeutic agents into living organisms; to control and/or improve the delivery of biologically active agents to cells, tissues, organs or organelles; to increase the level of specificity in targeting particular cells or cells types; and/or, to enhance the activity of such therapeutic agents once they enter an organism. The vehicle described in the present invention is used to carry and deliver biologically active agents and can be used for biochemical, therapeutic, clinical, or other applications in organisms and cells including, but not limited to, delivery of DNA, RNA, PNA, polynucleotides and proteins into cells, tissues or organisms; gene delivery applications; <i>in vivo</i> gene therapy, <i>ex vivo</i> gene therapy or <i>in vitro</i> gene therapy; customized therapeutics; vaccination of organisms; genetic vaccination of organisms; and, delivery of pharmaceutical products or biologically active chemical, biochemical or biological agents into cells and organisms. |
