发明名称 |
MATERIALS AND METHODS FOR TREATMENT OF CANCER AND IDENTIFICATION OF ANTI-CANCER COMPOUNDS |
摘要 |
The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways <i>in vitro</i> or <i>in vivo</i> using cucurbitacin I, or a pharmaceutically acceptable salt or analog therof. Another aspect of the present invention concerns a method for screening candidate compoudns for JAK AND/or STAT3 inhibition and anti-tumor activity. |
申请公布号 |
WO02078617(A2) |
申请公布日期 |
2002.10.10 |
申请号 |
WO2002US11157 |
申请日期 |
2002.03.28 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA;SEBTI, SAID, M.;JOVE, RICHARD |
发明人 |
SEBTI, SAID, M.;JOVE, RICHARD |
分类号 |
A61K31/56;A61K31/58;A61K45/06;A61P35/00;G01N33/50;G01N33/68 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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