Snake venom protein A homologue and nucleic acid encoding the same.

摘要

Isolated nucleic acids chosen from 135 sequences given in the specification are new. An isolated nucleic acid (I) having at least 80% sequence identity to: a nucleotide sequence that encodes a polypeptide comprising an amino acid sequence chosen from 135 sequences given in the specification; or one of 135 nucleotide sequences (given in the specification). Independent claims are also included for: an isolated nucleic acid which comprises the full-length coding sequence of the DNA deposited under any of 135 ATTC accession numbers as given in the specification; a vector comprising (I); a host cell comprising the vector of (2); a process for producing PRO polypeptides comprising culturing the host cell of 93) under conditions suitable for expression of the PRO polypeptide and recovering the PRO polypeptide from the cell culture; an isolated PRO polypeptide having at least 80% sequence identity to an amino acid sequence chosen as above or encoded by a DNA as in (1); a chimeric molecule comprising a polypeptide as above fused to a heterologous amino acid sequence; an antibody which specifically binds to a PRO polypeptide as above; an isolated extracellular domain of a PRO polypeptide; an isolated PRO polypeptide lacking its associated signal peptide; and an isolated polypeptide having at least about 80% amino acid sequence identity to (8) or (9). ACTIVITY : None Given. MECHANISM OF ACTION : None Given.