| 摘要 |
<p>It is intended to provide novel hemopoietin receptor proteins, genes encoding the same and production and use thereof. Splicing variants of a human hemopoietin receptor gene NR10 are successfully isolated by PCR cloning. The protein encoded by the isolated genes occurs in two types, i.e., a transmembrane type and a soluble type. The expression of the gene encoding the transmembrane protein is found out in a tissue containing hematopoietic cells. Further, a mouse NR10 gene is identified and its full-length cDNA is isolated. Proteins encoded by these genes, which are novel hemopoietin receptor genes participating in immunomodulation and hematopoietic cell regulation (in vivo), are useful in searching for novel hematopoietic factors capable of functionally binding to the above receptor and developing remedies for immunological and hematopoietic diseases.</p> |
