Intermediates in the formation of antivirally active heterocyclic azahexane derivatives

摘要

A compound of formula XX or IV or a salt thereof wherein: R1 is methoxycarbonyl or ethoxycarbonyl, R2 is t-butyl and R3 is phenyl. A compound of formula XXIV or a salt thereof wherein: R13 and R14 are both hydrogen, R13 is H and R14 is an amino protecting group or are both amino-protecting groups, which are different from one another; R3 is optionally substituted phenyl and R4 is phenyl or cyclohexyl each substituted in the 4-position by unsaturated optionally substituted 5 to 8 membered heterocyclyl bonded via a ring carbon atom and having 1 to 4 hetero atoms of nitrogen, oxygen, sulphur, sulphinyl and sulphonyl provided that at least one salt-forming group is present. A compound of formula V or XXVI or a salt wherein: R15 is an amino-protecting group; R1 is alkoxycarbonyl; R2 is secondary or tertiary alkyl or alkylthio-alkyl, R3 is optionally substituted phenyl and R4 is phenyl or cyclohexyl each substituted in the 4-position by unsaturated optionally substituted 5 to 8 membered heterocyclyl bonded via a ring carbon atom and having 1 to 4 hetero atoms of nitrogen, oxygen, sulphur, sulphinyl and sulphonyl provided that at least one salt. The above compounds are useful as intermediates of a compound of formula (I) as depicted in NZ 332118.