发明名称 METHOD OF IMMUNOGLOBULIN PREPARATION PREPARING
摘要 medicine. SUBSTANCE: invention relates to protein substance-containing medicinal preparations. Invention is performed by the successive treatment of extract of the precipitate B (fraction III by Cohn's method) with chloroform in concentration from 0.1 to 3% and copper sulfate in concentration from 0.1 to 2% at pH value 6-8. The isolation of the end product is carried out by ultrafiltration method in the presence of chelating compounds. The advantage of the invention involves the enhancement of biological activity of the end product due to increase content of immunoglobulin of class M and decreased content of lipoproteids impurity. EFFECT: improved method of preparing, simplified technological process. 1 tbl
申请公布号 RU2189833(C2) 申请公布日期 2002.09.27
申请号 RU20000126310 申请日期 2000.10.19
申请人 MOSKOVSKIJ NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT EHPI;DEMIOLOGII I MIKROBIOLOGII IM 发明人 ZORIK A.V.;ALESHKIN V.A.;LJUTOV A.G.;BORISOVA I.V.
分类号 A61K39/395;A61K35/16;(IPC1-7):A61K39/395 主分类号 A61K39/395
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