<p>N-type calcium channel deficient non-human animals whose gene for the calcium channel has been disrupted, are new. N-type calcium channel deficient non-human animals whose gene for the calcium channel has been disrupted, are new. The gene that is disrupted has a defined sequence given in the specification (S1) or encodes the N-type calcium channel alpha 1B subunit and hybridizes under stringent conditions to sequence (S1). Independent claims are also included for the following: (1) a method for assaying usefulness of substances using the animal; (2) a method for screening for substances with potential pharmacological use; (3) useful substances found by the method; and (4) a method for producing pharmaceuticals using this method (specifically methods for producing a hypotensive drug, a pain killer and a drug for lowering blood sugar and the substances themselves). ACTIVITY : Hypotensive; Analgesic.</p>
