LIPOXIN ANALOGS AS NOVEL INHIBITORS OF ANGIOGENESIS

摘要

The present invention is directed to methods for the prevention or inhibition of angiogenesis. The method is accomplished by the administration of an effective amount of 15-epi-16-( para -fluoro)-phenoxy-lipoxin A>4<, LXA>4<, 15-epi-LXA>4< or 15- R/S -methyl, LXA>4< and pharmaceutically acceptable salts, esters, amides, carboxylic acids, or prodrugs thereof, to a subject in need thereof. As a consequence of the action of the therapeutic agent, angiogenesis is prevented or inhibited in the subject.