发明名称 |
MODIFIED PROTAMINE WITH REDUCED IMMUNOGENICITY |
摘要 |
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for th e polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of protamin e to result in protamine proteins that are substantially non-immunogenic or le ss immunogenic than any non-modified counterpart when used in vivo.
|
申请公布号 |
CA2439929(A1) |
申请公布日期 |
2002.09.12 |
申请号 |
CA20022439929 |
申请日期 |
2002.03.01 |
申请人 |
MERCK PATENT GMBH |
发明人 |
CARR, FRANCIS J.;CARTER, GRAHAM |
分类号 |
C12N15/09;A61K35/60;A61K38/00;A61K38/16;A61P3/10;C07K14/46;C12P21/02;(IPC1-7):A61K38/16 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|