| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing an optically active 7-amino-5- azaspiro[2.4]heptane which is a raw material for synthesizing antibacterial compounds. SOLUTION: This method for producing the 7-amino-5-azaspiro[2.4]heptane is characterized by reacting a compound represented by formula (1) (R<1> is H or an amino-protecting group) with a compound represented by the formula: R<2> -NH2 (R<2> is H or an amino-protecting group) in the presence of an acid, hydrogenating the produced compound represented by formula (2) (R<1> and R<2> are each independently the same as described above) in the presence of an asymmetric catalyst, and, if desired, removing the protecting group. The highly optically pure 7-amino-5-azaspiro[2.4]heptane having a high optical purity can be produced using a catalytic amount of the asymmetric source in a high yield. |
