| 摘要 |
A method is disclosed for revascularizing ischemic tissue by creating a continuous channel from a non-ischemic to an ischemic area of the myocardium. A penetrating tip at the distal end of a catheter is advanced through specific areas of the myocardium. Healing of the channel results in angiogenesis of new blood vessels along its path, thus establishing a continuous vascular connection between the vascular beds in the non-ischemic myocardium and in the ischemic myocardium. The channel may originate from a blood vessel on the heart or from the inner or outer surface thereof. Preferably, the channel comprises a split path, formed by separating a thin layer of myocardium rather than creating a hole therethrough. Growth of the new blood vessels is further enhanced by placing an angiogenic growth factor in at least a portion of the channel.
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