发明名称 |
MICROEMULSION PREPARATION CONTAINING A SUBSTANCE WHICH IS DIFFICULT TO BE ABSORBED |
摘要 |
<p>A microemulsion preparation wherein aqueous phase droplets, which contain a lowly absorbable, physiologically active substance and has an average particle size of 0.4 to 100 nm, are dispersed in an oily phase dispersion medium with the combined use of a number of specified surfactants. To improve the poor percutaneous/permucous absorbability of a physiologically active substance, said substance is dissolved in the aqueous phase droplets of a W/O microemulsion. Neither any higher alcohol having an offensive odor nor any conventional absorption promoter is used in this microemulsion, and it is possible to provide a microemulsion preparation with a low local pungency.</p> |
申请公布号 |
EP0753311(B1) |
申请公布日期 |
2002.09.04 |
申请号 |
EP19940912700 |
申请日期 |
1994.04.19 |
申请人 |
INSTITUTE FOR ADVANCED SKIN RESEARCH INC. |
发明人 |
TAKAHASHI, MASAO;MATSUSHITA, HIROSHI |
分类号 |
A61K9/107;(IPC1-7):A61K47/06 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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