发明名称 |
RECOMBINANT VECTOR CONTAINING INFECTIOUS HUMAN CYTOMEGALOVIRUS GENOME WITH PRESERVED WILD-TYPE CHARACTERISTICS OF CLINICAL ISOLATES |
摘要 |
A recombinant vector containing infectious genome of human cytomegalovirus (HCMV) and being useful for the production of reconstituted HCMV virus retaining phenotypic characteristics of a clinical virus isolate including the ability to grow on endothelial cells and to induce microfusion is characterized in that it is obtainable by inserting DNA from a clinical isolate of HCMV virus into a bacterial cloning vehicle. Such vector can be used e.g. for production of reconstituted HCMV virus retaining the phenotypic characteristics of a parental clinical isolate and for studying genes and functions of genes of HCMV virus. A further aspect are mutant viruses and inter alia their use for studying aspects of infectivity of HCMV virus. |
申请公布号 |
WO02066629(A2) |
申请公布日期 |
2002.08.29 |
申请号 |
WO2002EP01867 |
申请日期 |
2002.02.21 |
申请人 |
HAHN, GABRIELE |
发明人 |
HAHN, GABRIELE |
分类号 |
A61K39/245;A61K48/00;C12N1/21;C12N7/00;C12N7/01;C12N7/04;C12N15/00;C12N15/33;C12N15/869 |
主分类号 |
A61K39/245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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