| 摘要 |
<p>An exogenous pharmaceutical preparation in which a lipid tagged bioactive material is combined with albumin is disclosed. The albumin has a low proportion of lipidic/fatty acid groups (a molar ratio of fatty acid groups to albumin of less than 0.7) and is preferably fatty acid free. The albumin may be naturally extracted such as Human Serum Albumin or recombinantly produced. A range of bioactive substances, such as peptides, proteins or vaccines may be tagged and combined with albumin for human, veterinary or agricultural use. Several antimicrobial peptides are disclosed. Binding to the albumin mediates the biostability of the tagged bioactive material. Due to this stabilisation, the antimicrobial activity of a model lipopeptide is enhanced when combined with substantially fatty acid free-albumin. When bound to albumin, therefore, the model lipopeptide exerts an antimicrobial effect at a lower concentration than the model lipopeptide alone.</p> |
