BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS

摘要

Selective MMP-13 inhibitors are bicyclic pyrmidines of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or alkyl; R?2, R3, and R4¿ include hydrogen, halo, alkyl, C C(CH¿2?)m aryl; and X is O, S, SO, SO2, CH2, C=O, CHOH, NH, OR NR?5¿. A compound of the formula, or a pharmaceutically acceptable salt thereof, is useful for treating cancer or arthritis.