| 发明名称 |
THROMBIN INHIBITORS |
| 摘要 |
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)-N(R25)CH(R30)- wherein the nitrogen atom is attached to R1, and R25 and R30 are independently selected from the group consisting of hydrogen, C3-6cycloalkyl, and C1-6alkyl, or 2) wherein the nitrogen atom is attached to R1, and m is 0, 1, or 2.
|
| 申请公布号 |
CA2436176(A1) |
申请公布日期 |
2002.08.22 |
| 申请号 |
CA20022436176 |
申请日期 |
2002.02.05 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
STAAS, DONNETTE D.;LYLE, TERRY A.;STAUFFER, KENNETH J.;WILLIAMS, PETER D.;BARROW, JAMES C.;SANDERSON, PHILIP E.;NANTERMET, PHILIPPE G.;YOUNG, MARY BETH;SELNICK, HAROLD G. |
| 分类号 |
A61K31/401;A61K31/4439;A61K31/497;A61K38/55;A61P7/02;A61P9/10;C07D257/04;C07D401/04;C07D401/12;C07D401/14;C07D403/12;C07D403/14;C07D417/12;C07D521/00;C07K5/06;C07K5/062;C07K5/065;C07K5/072;C07K5/078;(IPC1-7):C07D417/12;C07D407/12;C07D409/12 |
主分类号 |
A61K31/401 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
