| 摘要 |
The invention relates to a novel human class II PI3-kinase and in particular the sequence of the isolated nucleic acid molecule and the encoded amino acid sequence. The novel human PI3-kinase is termed PI3K-C2alpha and has unique biochemical properties that characterize and distinguish it from known PI3-kinases. These include, amongst other things, resistance to the PI3-kinase inhibitors Wortmannin and LY294000, the lack of a p85 binding site, a divergent amino terminus and the absence of a polyproline motif which is typical of known type II PI3-kinases.
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