49937, 49931, and 49933, novel human transporter family members and uses thereof

摘要

The invention provides isolated nucleic acid molecules, designated HEAT nucleic acid molecules, which encode novel transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HEAT nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a HEAT gene has been introduced or disrupted. The invention still further provides isolated HEAT proteins, fusion proteins, antigenic peptides and anti-HEAT antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.