CHLAMYDIA ANTIGENS AND CORRESPONDING DNA FRAGMENTS AND USES THEREOF

摘要

The present invention provides nucleic acids, proteins and vectors for a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia , specifically C. pneumoniae . The method employs a vector containing a nucleotide sequence encoding a polypeptide of a strain of Chlamydia pneumoniae operably linked to a promoter to effect expression of the gene product in the host. The polypeptides are derived from C. pneumoniae and are selected from an ATP-binding cassette protein, a secretory locus ORF, an endopeptidase, a protease, a metalloprotease, CLP protease ATPase, a CLP protease subunit, a translycolase/transpeptidase, a CLPc protease and thioredoxin.