USE OF INHIBITORS TO MULTIDRUG RESISTANCE PROTEIN 5 (MRP5) TO ENHANCE INTRACELLULAR LEVELS OF CYCLIC NUCLEOTIDES

摘要

The present invention relates to a novel method for enhancing intracellular levels of cyclic nucleotides, in particular cyclic guanosine monophosphate (cGMP). The method involves administering to a host a therapeutically effective amount of an inhibitor to both MRP5 and phosphodiesterase or administering an inhibitor to MRP5 in combination with an inhibitor to phosphodiesterases. Also, methods for the identification of MRP5 inhibitors, for treating conditions under which higher intracellular levels of cGMP are desirable or for treating MRP5-mediated drug resistance are provided.