摘要 |
<p>A compound of formula (I) wherein Ring A is imidazol[1,2a]pyrid3yl or pyrazolo[2, 3a]pyrid3yl; R2 is as defined within; m is 05; wherein the values of R2 may be the same or different; R1 is as defined within; n is 0 to 2, wherein the values of R1 may be the same or different; Ring B is phenyl or phenyl fused to a C57cycloalkyl ring; R3 is as defined within; p is 04; wherein the values of R3 may be the same or different; R4 is as defined within; q is 02; wherein the values of R4 may be the same or different; and wherein pplus;qle;5; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the inhibition of cell cycle kinases CDK2, CDK4, and CDK6 are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.</p> |