发明名称 |
ANTITHROMBOGENIC POLYMER COATING |
摘要 |
An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin. |
申请公布号 |
WO02058758(A2) |
申请公布日期 |
2002.08.01 |
申请号 |
WO2001US44597 |
申请日期 |
2001.11.29 |
申请人 |
MICHIGAN BIOTECHNOLOGY INSTITUTE |
发明人 |
HUANG, ZHI, HENG;MCDONALD, WILLIAM, F.;WRIGHT, STACY, C.;TAYLOR, ANDREW, C. |
分类号 |
A61L33/00;C08L79/02 |
主分类号 |
A61L33/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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