发明名称 DIAMINORHODAMINE DERIVATIVES
摘要 A compound represented by the following general formula: <CHEM> wherein R<1> and R<2> represent amino groups present at adjacent positions each other on the phenyl ring; R<3>, R<4>, R<5> and R<6> independently represent a C1-6 alkyl group; R<7>, R<8>, R<9> and R<10> independently represent a hydrogen atom, a C1-6 alkyl group, an allyl group, or a halogen atom; R<11> represents a hydrogen atom or a C1-18 alkyl group; and X<-> represents an anion, and an agent for nitric oxide measurement comprising said compound. The compound efficiently reacts with nitric oxide to give a fluorescent compound that emits strong fluorescence by irradiation with excitation light of a long wavelength. This fluorescent compound is characterized in that said compound is detectable in a fluorescence wavelength range hardly influenced by autofluorescence of cells, and its fluorescence intensity is not attenuated under an acidic condition.
申请公布号 EP1000941(A4) 申请公布日期 2002.07.31
申请号 EP19980929754 申请日期 1998.06.30
申请人 NAGANO, TESTUO 发明人 NAGANO, TETSUO;KOJIMA, HIROTATSU, ADACHI
分类号 A61K31/352;C07D249/04;C07D311/82;C07D311/88;C07D311/96;C07D493/10;G01N31/22;G01N33/00;(IPC1-7):C07D311/84;G01N21/78;C07D311/90;G01N33/52 主分类号 A61K31/352
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