发明名称 |
NOVEL METHOD AND COMPOSITION FOR INHIBITION OF ANGIOGENESIS USING ANTAGONISTS BASED ON MMP-9 AND beta 1 INTEGRINS |
摘要 |
Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or beta 1 integrins are described. Such antagonists inhibit angiongenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or beta 1 integrins are also described.
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申请公布号 |
WO0104157(A9) |
申请公布日期 |
2002.07.25 |
申请号 |
WO2000US19095 |
申请日期 |
2000.07.13 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
BROOKS, PETER, C.;HASSANIEH, LOUBNA;RODRIGUEZ, DOROTHY |
分类号 |
G01N33/50;A61K38/00;A61K39/395;A61K45/00;A61P9/00;A61P17/06;A61P25/00;A61P35/00;A61P35/04;C07K14/705;C07K16/28;C07K16/40;C12N9/50;C12P21/08;G01N33/15;G01N33/53;G01N33/566;(IPC1-7):A61K39/395;A61K31/00;A61K31/708;A61K47/48;A61K51/00 |
主分类号 |
G01N33/50 |
代理机构 |
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地址 |
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