发明名称 |
Compositions and methods for treatment of Hepatitis C virus-associated diseases |
摘要 |
Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.
|
申请公布号 |
US6423489(B1) |
申请公布日期 |
2002.07.23 |
申请号 |
US19950452841 |
申请日期 |
1995.05.30 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
ANDERSON KEVIN P.;HANECAK RONNIE C.;HOSHIKO KAZUYA;NOZAKI CHIKATERU;NISHIHARA TSUKASA;NAKATAKE HIROSHI;HAMADA FUKUSABURO;ETO TATSUO;FURUKAWA SHINICHI;FURUSAKO SHOJI;BRUICE THOMAS W.;LIMA WALTER F. |
分类号 |
C07H21/00;C07K14/18;C12N15/113;C12Q1/70;(IPC1-7):C12Q1/68;C07H21/04;C12N15/85 |
主分类号 |
C07H21/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|