NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

摘要

A compound of formula (I), wherein B is a phenyl ring, a 5 to 10 membered heteroaromatic group containing one or more heteroatoms, or a naphthalenyl, 5, 6, 7, 8- tetrahydronaphthalenyl, benzo[1,3]dioxolyl, or biphenyl group; R1, R2 and R3 each independently represent a hydrogen or halogen atom, or a hydroxy group, a phenyl group, -OR<7>, -SR<7>, -NR<7>R<8>, -NHCOR<7>, -CONR<7>R<8>, -CN, -NO2, -COOR<7> or CF3 group, or a strait or branched, substituted or unsubstituted lower alkyl group, wherein R<7> and R<8> each independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; or R<1> and R<2> together form an aromatic or alicyclic ring or a heterocyclic group. n is an integer from 0 to 4; A represents a group selected from -CH2-, -CH=CR<9>-, -CR<9>=CH-, -CR<9>R<10>-, -CO-, -O-, -S-, -S(O)-, -S(O)2- and NR<9>, wherein R<9> and R<10> each independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; m is an integer from 0 to 8, provided that when m=0, A is not -CH2-; p is an integer from 1 to 2 and the substitution in the azonia bicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; R4 represents a group of structure: (Formulae II) wherein R<11> represents a hydrogen or halogen atom, a hydroxy group, an alkoxy group, a nitro group, a cyano group, -CO2R<12> or -NR<12>R<13>, wherein R<12> and R<13> are identical or different and are selected from hydrogen and straight or branched lower alkyl groups, or a straight or branched, substituted or unsubstituted lower alkyl group; R<5> represents an alkyl group of 1 to 7 carbon atoms, an alkenyl group containing 2 to 7 carbon atoms, or a group of formula (III) wherein q=1 or 2 and R<11> iss a defined above; R<6> represents a hydrogen atom, a hydroxy group, a methyl group or a -CH2OH group; and X<-> represents a pharmaceutically acceptable anion of a mono or polyvalent acid.