| 发明名称 |
Mutants of thymidylate synthase and uses thereof |
| 摘要 |
The present invention provides a mutated human TS, said mutated synthase differing from wild type TS at amino acid residue 49, amino acid residue 52, amino acid residue 108, amino acid residue 221 or amino acid residue 225. Also provided is cDNA mutated human TSs and novel vectors and host cells and methods of using the mutated human TSs.
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| 申请公布号 |
US6416987(B1) |
申请公布日期 |
2002.07.09 |
| 申请号 |
US19990367007 |
申请日期 |
1999.08.04 |
| 申请人 |
SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
LIU-CHEN XINYUE;TONG YOUZHI;BERTINO JOSEPH R.;BANERJEE DEBABRATA |
| 分类号 |
A61K38/00;C12N9/10;C12N15/54;(IPC1-7):C12N9/12 |
主分类号 |
A61K38/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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