Composition and method for enhancing immunological memory response

摘要

A strategy for inducing immune T lymphocytes to respond in such a fashion to their target antigen at first exposure so as to enable them to mount a response of greater magnitude upon any subsequent exposure to the same target is provided. The strategy involves exposure of T cells or animals being immunized to the commonly used phosphodiesterase inhibitor drug, pentoxifylline (POX/PF/Trental), during immune priming. Evidence is provided showing that such exposure leads to enhancement of immune T cells responses upon re-exposure. The strategy is relevant and useful for increasing the efficiency of vaccinations.