发明名称 |
Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs |
摘要 |
A process for the recombinant preparation of a calcitonin fragment and the use of the fragment in the preparation of calcitonin and related analogs is provided. The process includes recombinantly forming a fusion protein which includes the calcitonin fragment linked to a carbonic anhydrase. The recombinantly formed fusion protein is subsequently cleaved to produce a polypeptide which includes the calcitonin fragment. A method for producing a calcitonin carba analog which includes condensing a desaminononapeptide with the recombinantly formed calcitonin fragment is also provided.
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申请公布号 |
US6410707(B2) |
申请公布日期 |
2002.06.25 |
申请号 |
US20010750913 |
申请日期 |
2001.01.02 |
申请人 |
BIONEBRASKA, INC. |
发明人 |
WAGNER FRED W.;STOUT JAY S.;HENRIKSEN DENNIS B.;PARTRIDGE BRUCE E.;HOLMQUIST BART;FRANK JULIE A. |
分类号 |
C07K14/585;C12N9/88;C12N15/16;(IPC1-7):C07H21/04;C12N1/20;C12N15/00;A61K38/00;C12P21/04 |
主分类号 |
C07K14/585 |
代理机构 |
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代理人 |
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地址 |
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