| 摘要 |
The invention relates to compounds of general formula (I): and formula (II): wherein R1, R2, R3, R4, R5, X1, X2, X3, X4, X5 and Y are defined as per the description. The compounds of formula (I) and (II) inhibit cyclin-dependent kinases (CDKs) and additional kinases (KDR), have cytostatic properties and are particularly suitable for treating tumours. The compounds of formulas (I) and (II) can be obtained by extraction of the plant Uvaria klaineri, PLA 100484, by cell cultures of the plant Uvaria klaineri or by chemical synthesis. The invention also relates to a method for producing the compounds of formulas (I) and (II), to the use of said compounds for producing a medicament for treating malignant diseases and diseases that can be treated by inhibiting CDKs and KDR.
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