| 摘要 |
<p>Novel substituted carboxylic acid derivatives which bind to human peroxisome proliferator-activated receptor α (PPARα) as a ligand thereof and activate the same, thereby being efficacious as remedies for metabolic diseases such as lipid-lowering drugs (particularly in the liver), drugs preventing the progress of arteriosclerosis, anti-obesity drugs and remedies for diabetes; and a process for producing the same. Namely, substituted carboxylic acid derivatives represented by the following general formula (1), esters thereof and pharmaceutically acceptable salts and hydrates of the same; and a process for producing these compounds: (1) wherein R1 represents hydrogen, halogeno, hydroxy, 2-phenylethyl, 2-phenylethoxy, hydroxyphenoxy or benzyloxyphenoxy; and R2 represents lower (C¿1-4?) alkyl.</p> |
