| 摘要 |
The invention provides a process for the optical resolution of a racemic mixture, or an otpionally enriched mixture, of trans-7-(hydromethyl)octa-hydro- 2H-pyrido-1,2a)pyrazine, a key intermediate for preparing pharmacologically active 2,7-substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives useful in the treatment of disorders of the dopamine system. The process of the invention involves use of D-(-) or L-(+)naporxen as a resolving agent.
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