| 发明名称 |
Process for the preparation of alpha' chloroketones |
| 摘要 |
The present invention relates to a process for the preparation of alpha' chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1-chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t-butoxycarbonyl)-L-phenylalanine-4-nitrophenyl ester, with a sulfur ylide compound to form the corresponding keto ylide compound which is then treated with a source of chloride and an organic acid.
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| 申请公布号 |
US6399793(B1) |
申请公布日期 |
2002.06.04 |
| 申请号 |
US20010908516 |
申请日期 |
2001.07.18 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
KRONENTHAL DAVID;SCHWINDEN MARK D. |
| 分类号 |
C07D303/46;C07C221/00;C07C269/06;C07C271/16;C07C271/18;C07C315/04;C07C317/28;C07D303/36;(IPC1-7):C07D301/02 |
主分类号 |
C07D303/46 |
| 代理机构 |
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