| 摘要 |
An immortalized human cell line has the characteristics of human microglia. It expresses the CD 8 and CD11c antigens. The immortalized human cell line has at least three of the following attributes: CD11b (Mac1), CD68, HLA-ABC, HLA-DR, IL-1b, IL-6, IL-8, IL-12, IL-15, TGF-b, TNF-a, MIP-1a, MIP-1b, MCP-1, P2Y1R, P2Y2R. Also disclosed is a method of transforming human microglial cells into an immortalized cell line, a method of testing drugs for effects on human microglial cells and a method of treating individuals experiencing neurodegenerative disorders.
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