发明名称 |
IMIDAZOLE AND BENZIMIDAZOLE CASPASE INHIBITORS AND USES THEREOF |
摘要 |
This invention provides caspase inhibitors having the formula (I): wherein R<1> is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R<2> and R<3> are each independently selected from hydrogen or an optionally substituted C1-C6 aliphatic group; and R<4> and R<5> are each independently selected from hydrogen, an optionally substituted C1-C6 aliphatic group, or R<4> and R<5> taken together with the ring to which they are attached form an optionally substituted bicyclic ring. The caspase inhibitors are useful for treating a number of diseases such as cancer, acute inflammatory and autoimmune disorders, ischemic diseases and certain neurodegenerative disorders. |
申请公布号 |
WO0242278(A2) |
申请公布日期 |
2002.05.30 |
申请号 |
WO2001US47688 |
申请日期 |
2001.11.19 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;KAY, DAVID;GOLEC, JULIAN |
发明人 |
KAY, DAVID;GOLEC, JULIAN |
分类号 |
C07D233/28;A61K31/4164;A61K31/4184;A61K38/00;A61K45/00;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P5/14;A61P7/04;A61P7/06;A61P7/08;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/02;A61P17/06;A61P17/14;A61P19/02;A61P19/10;A61P21/00;A61P21/04;A61P25/00;A61P25/02;A61P25/08;A61P25/14;A61P25/16;A61P25/28;A61P25/32;A61P27/02;A61P29/00;A61P31/00;A61P31/04;A61P31/06;A61P31/12;A61P31/18;A61P35/00;A61P35/02;A61P37/02;A61P37/06;A61P43/00;C07D233/00;C07D233/90;C07D235/24;C07K5/02;C07K5/078 |
主分类号 |
C07D233/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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