BLOCKADE OF SODIUM CHANNELS BY PHENOL DERIVATIVES

摘要

The invention relates to a pharmaceutical composition comprising at least one phenol derivative represented by formula (I), wherein R<1> represents a hydrogen atom, a halogen atom or a hydrocarbon group containing up to 12 carbon atoms; R<2> represents a hydrogen atom or a C1-C7 alkyl group; wherein R<1> and R<2> may optionally form a carbocyclic 5- or 6-membered ring; R<3> represents a hydrogen atom, a halogen atom or a C1-C7 alkyl group; R<4> represents a hydrogen atom, a C1-C7 alkyl group or a halogen atom; R<5> represents hydrogen atom, a halogen atom or a C1-C7 alkyl group; and R<6> represents a hydrogen atom, a C1-C7 alkyl group or a C2 or C3 alkenyl group, under the proviso that R<2> and R<4> can only both represent a hydrogen atom if both R<1> and R<5> represent a C1-C7 alkyl group and R<3> represents a halogen atom. The composition is particularly useful for the blockade of sodium channels and/or influencing the kinetics of sodium channels and thus can be used as local anesthetic, antidysrhythmic, anticonvulsant/antiepileptic and spasmolytic.