发明名称 |
HIV chemokines |
摘要 |
Disclosed is a gene comprising an open reading frame encoded on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is related to, and has a structural motif resembling that of chemokine proteins. Depending upon the ribosomal frameshift, a plurality of proteins may be translated from the antisense RNA. The protein has similarity with chemokine SDF-1 and may play a role as a cofactor with gp120 in the binding to and entry of HIV to a target cell.
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申请公布号 |
US6392029(B1) |
申请公布日期 |
2002.05.21 |
申请号 |
US19990249542 |
申请日期 |
1999.02.12 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
LUDWIG LINDA B.;AMBRUS, JR. JULIAN L.;KRAWCZYK KRISTIE ANNE |
分类号 |
A61K38/00;A61K39/00;C07K14/16;C12N15/113;(IPC1-7):C07H21/00;C12N7/01;C12N15/49 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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